A 69-year-old man with Parkinson disease on levodopa-carbidopa three times a day reports wearing-off phenomena with increased rigidity and tremor 3 ho...

Question

A 69-year-old man with Parkinson disease on levodopa-carbidopa three times a day reports wearing-off phenomena with increased rigidity and tremor 3 hours after each dose. What is the most appropriate adjustment to improve motor fluctuations?

Accepted Answer

Add a COMT inhibitor to each levodopa dose

Answer

Stop levodopa and switch to anticholinergic monotherapy

Answer

Increase levodopa dosing interval to twice daily

Answer

Start high-dose benzodiazepines

Answer

Add long-term oral corticosteroids

au-racp MCQ (SBA): Parkinson disease motor fluctuations

A 69-year-old man with Parkinson disease on levodopa-carbidopa three times a day reports wearing-off phenomena with increased rigidity and tremor 3 hours after each dose. What is the most appropriate adjustment to improve motor fluctuations?