A 70-year-old man with type 2 diabetes and chronic kidney disease presents with oedema, weight gain and rising creatinine after starting high-dose ibuprofen for back pain. Which mechanism best explains the acute kidney injury?AReduced renal perfusion due to NSAID-induced afferent arteriolar vasoconstrictionBImmune complex deposition in glomeruliCObstructive uropathyDDirect tubular toxicity of insulinEPrerenal azotaemia due to ACE inhibitor aloneCheck my answer