A 32-year-old woman with confirmed rheumatoid arthritis has persistent synovitis in multiple small joints despite regular NSAIDs. Rheumatoid factor an...

Question

A 32-year-old woman with confirmed rheumatoid arthritis has persistent synovitis in multiple small joints despite regular NSAIDs. Rheumatoid factor and anti-CCP antibodies are positive. What is the most appropriate next step in disease-modifying therapy?

Accepted Answer

Start Methotrexate as a conventional synthetic DMARD

Answer

Continue NSAIDs only and review in 12 months

Answer

Start long-term high-dose oral Prednisolone as monotherapy

Answer

Start biologic therapy without trying conventional DMARDs

Answer

Use Paracetamol only

au-amc MCQ (SBA): Rheumatoid arthritis

A 32-year-old woman with confirmed rheumatoid arthritis has persistent synovitis in multiple small joints despite regular NSAIDs. Rheumatoid factor and anti-CCP antibodies are positive. What is the most appropriate next step in disease-modifying therapy?