Question

A 29-year-old woman presents with chronic diarrhoea and weight loss. Serology shows positive IgA tissue transglutaminase antibodies with normal total IgA. What is the most appropriate next step to confirm the diagnosis?

Accepted Answer

Small bowel biopsy via upper endoscopy

Answer

Start a strict gluten-free diet immediately without further tests

Answer

HLA typing only

Answer

Colonoscopy with random biopsies

Answer

Faecal calprotectin measurement

Practice question

A 29-year-old woman presents with chronic diarrhoea and weight loss. Serology shows positive IgA tissue transglutaminase antibodies with normal total IgA. What is the most appropriate next step to confirm the diagnosis?