A 28-year-old man develops jaundice and dark urine 2 days after starting trimethoprim-sulfamethoxazole for a urinary tract infection. He has a known G...

Question

A 28-year-old man develops jaundice and dark urine 2 days after starting trimethoprim-sulfamethoxazole for a urinary tract infection. He has a known G6PD deficiency. Laboratory tests show anaemia with elevated LDH and indirect bilirubin. What is the most appropriate management?

Accepted Answer

Stop trimethoprim-sulfamethoxazole and provide supportive care

Answer

Continue the antibiotic and observe

Answer

Start high-dose IV corticosteroids

Answer

Begin iron supplementation

Answer

Perform urgent splenectomy

ca-mccqe1 MCQ (SBA): G6PD deficiency haemolysis

A 28-year-old man develops jaundice and dark urine 2 days after starting trimethoprim-sulfamethoxazole for a urinary tract infection. He has a known G6PD deficiency. Laboratory tests show anaemia with elevated LDH and indirect bilirubin. What is the most appropriate management?