Question

A 72-year-old man on warfarin for atrial fibrillation presents with massive gastrointestinal bleeding and haemodynamic instability. His INR is 4.5. What is the most appropriate strategy for rapid reversal of anticoagulation?

Accepted Answer

Intravenous vitamin K plus four-factor prothrombin complex concentrate (PCC)

Answer

Stop warfarin only and observe

Answer

Vitamin K orally only

Answer

Fresh frozen plasma alone

Answer

No reversal; bleeding will stop spontaneously

Practice question

A 72-year-old man on warfarin for atrial fibrillation presents with massive gastrointestinal bleeding and haemodynamic instability. His INR is 4.5. What is the most appropriate strategy for rapid reversal of anticoagulation?