A 28-year-old woman presents with iron deficiency anaemia and chronic diarrhoea. Coeliac serology shows markedly elevated tissue transglutaminase IgA ...

Question

A 28-year-old woman presents with iron deficiency anaemia and chronic diarrhoea. Coeliac serology shows markedly elevated tissue transglutaminase IgA and positive endomysial antibodies. She has not yet changed her diet. What is the most appropriate next step to confirm the diagnosis?

Accepted Answer

Duodenal biopsy via upper gastrointestinal endoscopy

Answer

Start a strict gluten-free diet immediately without further investigation

Answer

HLA typing for DQ2 and DQ8 only

Answer

CT abdomen with contrast

Answer

Capsule endoscopy to assess the small bowel

au-amc MCQ (SBA): Coeliac disease

A 28-year-old woman presents with iron deficiency anaemia and chronic diarrhoea. Coeliac serology shows markedly elevated tissue transglutaminase IgA and positive endomysial antibodies. She has not yet changed her diet. What is the most appropriate next step to confirm the diagnosis?