A 17-year-old girl presents with a widespread, intensely pruritic vesicular rash after starting lamotrigine 2 weeks ago. She is febrile and has mucosa...

Question

A 17-year-old girl presents with a widespread, intensely pruritic vesicular rash after starting lamotrigine 2 weeks ago. She is febrile and has mucosal involvement. Stevens-Johnson syndrome is suspected. What is the most appropriate immediate management?

Accepted Answer

Stop lamotrigine and arrange urgent transfer to a burns or intensive care unit

Answer

Continue lamotrigine and add topical steroids

Answer

Start oral antihistamines only

Answer

Treat with topical emollients and review in a week

Answer

Switch to carbamazepine immediately without specialist advice

au-acem MCQ (SBA): Stevens-Johnson syndrome

A 17-year-old girl presents with a widespread, intensely pruritic vesicular rash after starting lamotrigine 2 weeks ago. She is febrile and has mucosal involvement. Stevens-Johnson syndrome is suspected. What is the most appropriate immediate management?