HardRespiratoryAcute COPD exacerbation with hypercapnic respiratory failureau-acemau-amc
A 60-year-old man with COPD develops an acute exacerbation with PaCO2 60 mmHg and pH 7.30 on arterial blood gas despite optimal medical therapy and controlled oxygen. He is drowsy but arousable. What is the MOST appropriate next step?