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MediumPsychiatryMajor depressive disorderca-mccqe1ca-ccfpca-rcpsc-im

A 38-year-old man presents with a 2-month history of low mood, anhedonia, insomnia, and impaired concentration. He denies substance use, psychosis, or suicidal intent. According to CANMAT 2023 guidelines, which of the following is an appropriate first-line pharmacologic option for major depressive disorder?

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