A 62-year-old man with long-standing hypertension and diabetes is brought to the emergency department with sudden onset right-sided weakness and aphasia 90 minutes ago. CT brain shows no haemorrhage. NIHSS is 14. Blood pressure is 178/96 mm Hg, glucose 8.1 mmol/L. There are no contraindications to thrombolysis. According to Canadian Stroke Best Practice Recommendations, what is the most appropriate next step?