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EasyPsychiatryMajor depressive disorder initial pharmacotherapyau-racgpau-amc

A 35-year-old woman presents with persistent low mood, anhedonia, early morning wakening and impaired functioning for 2 months. There is no history of mania or psychosis. She has no suicidal plan but occasional passive thoughts of death. What is the most appropriate initial pharmacological management in general practice?

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