Question

A 70-year-old man on warfarin for atrial fibrillation presents with massive gastrointestinal bleeding and haemodynamic instability. His INR is 4.5. What is the most appropriate strategy for rapid reversal of anticoagulation?

Accepted Answer

Administer prothrombin complex concentrate (PCC) plus intravenous vitamin K

Answer

Withhold warfarin only

Answer

Give intravenous vitamin K alone

Answer

Administer fresh frozen plasma alone

Answer

Switch from warfarin to a direct oral anticoagulant

Practice question

A 70-year-old man on warfarin for atrial fibrillation presents with massive gastrointestinal bleeding and haemodynamic instability. His INR is 4.5. What is the most appropriate strategy for rapid reversal of anticoagulation?