A 31-year-old man with schizophrenia has persistent positive symptoms despite adequate trials of two different antipsychotics at therapeutic doses for...

Question

A 31-year-old man with schizophrenia has persistent positive symptoms despite adequate trials of two different antipsychotics at therapeutic doses for at least 6 weeks each with good adherence. What is the recommended next pharmacological step?

Accepted Answer

Switch to clozapine

Answer

Add benzodiazepines to existing antipsychotic

Answer

Increase the current antipsychotic to supra-therapeutic doses

Answer

Add an antidepressant

Answer

Stop all antipsychotics and use psychological therapy alone

au-racp MCQ (SBA): Treatment-resistant schizophrenia

A 31-year-old man with schizophrenia has persistent positive symptoms despite adequate trials of two different antipsychotics at therapeutic doses for at least 6 weeks each with good adherence. What is the recommended next pharmacological step?