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MediumPsychiatryMajor depressive disorderca-mccqe1ca-ccfpca-rcpsc-im

A 45-year-old woman presents to her family physician with low mood, anhedonia, poor sleep and fatigue for 6 weeks. She meets diagnostic criteria for major depressive disorder of moderate severity and has no psychotic features or significant suicide risk. According to CANMAT 2016 depression guidelines, which of the following is recommended as an initial treatment approach?

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