A 59-year-old man presents with 40 minutes of severe central chest pain and diaphoresis. ECG shows 3 mm ST elevation in leads II, III and aVF with reciprocal changes in aVL. He is in a regional hospital with on-site thrombolysis but percutaneous coronary intervention (PCI) is 3.5 hours away. Symptoms began 1 hour ago. What is the most appropriate reperfusion strategy?