Question

A 52-year-old woman presents with new onset symmetrical small joint pain and morning stiffness lasting >1 hour for 3 months. Examination shows synovitis of MCP and PIP joints. RF and anti-CCP antibodies are positive. What is the most appropriate initial disease-modifying therapy?

Accepted Answer

Methotrexate

Answer

Prednisone alone

Answer

NSAIDs alone

Answer

Hydroxychloroquine only

Answer

Biologic therapy as first-line

Practice question

A 52-year-old woman presents with new onset symmetrical small joint pain and morning stiffness lasting >1 hour for 3 months. Examination shows synovitis of MCP and PIP joints. RF and anti-CCP antibodies are positive. What is the most appropriate initial disease-modifying therapy?