A 52-year-old man presents with symmetrical small joint pain and morning stiffness lasting more than 1 hour for 3 months. Examination shows synovitis ...

Question

A 52-year-old man presents with symmetrical small joint pain and morning stiffness lasting more than 1 hour for 3 months. Examination shows synovitis of the metacarpophalangeal and proximal interphalangeal joints bilaterally. Rheumatoid factor and anti-CCP antibodies are positive. What is the most appropriate initial disease-modifying therapy in Australian practice?

Accepted Answer

Methotrexate with folate supplementation

Answer

High-dose Prednisolone monotherapy

Answer

Hydroxychloroquine alone

Answer

Non-steroidal anti-inflammatory drugs only

Answer

Biologic TNF inhibitor as first-line

au-amc MCQ (SBA): Rheumatoid arthritis