A 64-year-old man presents to the emergency department with 90 minutes of central chest pain radiating to the left arm, associated with diaphoresis and nausea. ECG shows 3 mm ST elevation in leads V2-V4 with reciprocal depression inferiorly. He has no contraindications to reperfusion therapy and the nearest PCI-capable centre is 3 hours away by road. What is the most appropriate immediate reperfusion strategy?