Question

A 68-year-old man with atrial fibrillation on apixaban presents with severe sepsis from pneumonia and hypotension. He is oliguric, and creatinine has risen acutely from 90 to 260 µmol/L. What is the most appropriate action regarding his apixaban?

Accepted Answer

Temporarily withhold apixaban and reassess renal function and bleeding risk

Answer

Continue apixaban at the same dose

Answer

Increase the apixaban dose due to sepsis-related thrombosis risk

Answer

Switch to warfarin immediately

Answer

Add aspirin without changing apixaban

Practice question

A 68-year-old man with atrial fibrillation on apixaban presents with severe sepsis from pneumonia and hypotension. He is oliguric, and creatinine has risen acutely from 90 to 260 µmol/L. What is the most appropriate action regarding his apixaban?