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HardPsychiatryTreatment-resistant depression - augmentationau-amcau-racp

A 45-year-old man presents with longstanding low mood, anhedonia and poor sleep. He has tried an SSRI and a serotonin-noradrenaline reuptake inhibitor (SNRI) at adequate doses without remission. He has no psychosis or bipolar disorder. According to treatment-resistant depression principles, which is the most appropriate next step?

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