Question

A 45-year-old man with confirmed rifampicin-susceptible pulmonary tuberculosis has been on appropriate four-drug therapy (isoniazid, rifampicin, pyrazinamide, ethambutol) under directly observed therapy for 8 weeks. His sputum smear is now negative. According to standard TB regimens, what is the usual next step?

Accepted Answer

Continue isoniazid and rifampicin for a further 4 months

Answer

Stop all drugs now as sputum has converted

Answer

Continue all four drugs for a total of 9 months

Answer

Switch to second-line injectable agents

Answer

Continue ethambutol only for 4 months

Practice question