Question

A 28-year-old woman is investigated for iron deficiency anaemia. Coeliac serology shows negative IgA tissue transglutaminase antibodies, but her total IgA level is markedly low. She remains symptomatic with diarrhoea and bloating. What is the most appropriate next investigation to evaluate for coeliac disease?

Accepted Answer

IgG deamidated gliadin peptide or IgG tissue transglutaminase antibody

Answer

HLA typing alone

Answer

Repeat IgA tissue transglutaminase antibody in 6 months

Answer

No further testing; coeliac disease excluded

Answer

Upper endoscopy for variceal screening

Practice question