Question

A 41-year-old man with dysuria and frequency also reports flank pain and fever 102.2°F. He is stable for outpatient management. UA suggests pyelonephritis; local E. coli TMP-SMX resistance is 15%. Best empiric regimen?

Accepted Answer

Oral fluoroquinolone (e.g., ciprofloxacin), if local resistance is acceptable

Answer

Nitrofurantoin for 5 days

Answer

Fosfomycin single dose

Answer

TMP-SMX for 3 days

Answer

Amoxicillin 500 mg TID

Practice question

A 41-year-old man with dysuria and frequency also reports flank pain and fever 102.2°F. He is stable for outpatient management. UA suggests pyelonephritis; local E. coli TMP-SMX resistance is 15%. Best empiric regimen?