Question

A 45-year-old woman has acute watery diarrhea after clindamycin use. Stool toxin NAAT is positive for Clostridioides difficile. First episode, non-severe, no significant comorbidities. Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg twice daily for 10 days

Answer

Oral metronidazole for 10 days

Answer

Oral vancomycin 125 mg four times daily for 10 days

Answer

Probiotics alone

Answer

Bezlotoxumab monotherapy

Practice question

A 45-year-old woman has acute watery diarrhea after clindamycin use. Stool toxin NAAT is positive for Clostridioides difficile. First episode, non-severe, no significant comorbidities. Best initial therapy?