A 41-year-old man with gout and CKD stage 3 (eGFR 45) has two flares per year and tophi. Best choice to start urate-lowering therapy?...

Question

A 41-year-old man with gout and CKD stage 3 (eGFR 45) has two flares per year and tophi. Best choice to start urate-lowering therapy?

Accepted Answer

Allopurinol ≤100 mg/day with titration

Answer

Febuxostat 80 mg/day starting dose

Answer

Probenecid monotherapy

Answer

Pegloticase first-line

Answer

No ULT; treat flares only

us-abim MCQ (SBA): Gout-Initiating ULT