A 36-year-old presents with watery diarrhea after recent antibiotics, WBC 18,000/µL, creatinine 2.1 mg/dL. This meets severe CDI criteria. Preferred i...

Question

A 36-year-old presents with watery diarrhea after recent antibiotics, WBC 18,000/µL, creatinine 2.1 mg/dL. This meets severe CDI criteria. Preferred initial therapy?

Accepted Answer

Fidaxomicin 200 mg PO bid (preferred) or vancomycin 125 mg PO qid

Answer

Metronidazole IV monotherapy

Answer

No antibiotics; probiotics only

Answer

Vancomycin 500 mg PO qid plus IV metronidazole for fulminant only

Answer

Bezlotoxumab alone

us-abim MCQ (SBA): C. difficile (Severe)

A 36-year-old presents with watery diarrhea after recent antibiotics, WBC 18,000/µL, creatinine 2.1 mg/dL. This meets severe CDI criteria. Preferred initial therapy?