Question

A 58-year-old with recurrent gout flares (3/year) and tophi has eGFR 50 mL/min/1.73 m². Best long-term urate-lowering approach?

Accepted Answer

Start allopurinol and titrate to serum urate <6 mg/dL

Answer

Lifestyle modification only

Answer

Start febuxostat as first-line in all

Answer

Probenecid despite CKD stage 3

Answer

Discontinue flare prophylaxis immediately

Practice question

A 58-year-old with recurrent gout flares (3/year) and tophi has eGFR 50 mL/min/1.73 m². Best long-term urate-lowering approach?