Question

A 36-year-old with iron-deficiency anemia (ferritin 12 ng/mL) has negative celiac serology (IgA sufficient). Next best diagnostic step for suspected celiac disease?

Accepted Answer

Upper endoscopy with duodenal biopsies

Answer

Start gluten-free diet and retest later

Answer

HLA-DQ2/DQ8 genotyping first

Answer

Repeat tTG-IgA after 6 months

Answer

Fecal calprotectin

Practice question

A 36-year-old with iron-deficiency anemia (ferritin 12 ng/mL) has negative celiac serology (IgA sufficient). Next best diagnostic step for suspected celiac disease?