A 70-year-old with new HFrEF on ACE inhibitor is being switched to sacubitril/valsartan. What safety step is required?...

Question

A 70-year-old with new HFrEF on ACE inhibitor is being switched to sacubitril/valsartan. What safety step is required?

Accepted Answer

Ensure 36-hour washout after last ACE inhibitor dose

Answer

Start ARNI the same day as ACE inhibitor for overlap

Answer

Add spironolactone before ARNI

Answer

Stop beta-blocker for 1 week before ARNI

Answer

Double diuretic dose first

us-abim MCQ (SBA): Heart Failure Pharmacotherapy