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EasyPsychiatryMajor Depressive Disorderus-abfmus-abimus-usmle-step-2us-usmle-step-3

A 32-year-old woman presents to primary care with low mood, anhedonia, fatigue, poor sleep, and impaired concentration for 8 weeks. She denies suicidal ideation, substance use, or medical comorbidities. Physical examination and basic labs are normal. She meets criteria for moderate major depressive disorder. She has not previously received treatment. Which is the most appropriate initial therapy?

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