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ModerateEndocrinologyPrimary hypothyroidism initial dosingus-abfmus-abimus-usmle-step-2us-usmle-step-3

A 36-year-old woman presents with fatigue, weight gain, constipation, and cold intolerance for 4 months. Examination shows dry skin and delayed relaxation of deep tendon reflexes. Laboratory tests reveal TSH 11 micro IU/mL and free T4 below normal. She is not pregnant and has no cardiovascular disease. What is the most appropriate initial dose of levothyroxine?

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