A 24-year-old man with schizophrenia presents with persistent auditory hallucinations and delusions despite adequate trials of risperidone and olanzap...

Question

A 24-year-old man with schizophrenia presents with persistent auditory hallucinations and delusions despite adequate trials of risperidone and olanzapine at therapeutic doses and durations. He is adherent and has no substance use. Which is the most appropriate next pharmacologic step?

Accepted Answer

Switch to clozapine

Answer

Increase olanzapine above maximum recommended dose

Answer

Add a benzodiazepine

Answer

Start electroconvulsive therapy instead of medications

Answer

Stop antipsychotics and start mood stabilizer

us-abfm MCQ (SBA): Treatment-Resistant Schizophrenia

A 24-year-old man with schizophrenia presents with persistent auditory hallucinations and delusions despite adequate trials of risperidone and olanzapine at therapeutic doses and durations. He is adherent and has no substance use. Which is the most appropriate next pharmacologic step?