A 28-year-old woman presents with fever, malar rash sparing the nasolabial folds, arthralgias, and photosensitivity. Labs show positive ANA and anti-d...

Question

A 28-year-old woman presents with fever, malar rash sparing the nasolabial folds, arthralgias, and photosensitivity. Labs show positive ANA and anti-dsDNA, low complement levels, and proteinuria. What is the most appropriate initial treatment to control systemic disease and renal involvement?

Accepted Answer

Oral prednisone plus mycophenolate mofetil

Answer

Topical corticosteroids only

Answer

NSAIDs alone

Answer

Hydroxychloroquine alone

Answer

Methotrexate monotherapy

us-abim MCQ (SBA): Systemic Lupus Erythematosus with Nephritis

A 28-year-old woman presents with fever, malar rash sparing the nasolabial folds, arthralgias, and photosensitivity. Labs show positive ANA and anti-dsDNA, low complement levels, and proteinuria. What is the most appropriate initial treatment to control systemic disease and renal involvement?