A 42-year-old man presents with polyuria, polydipsia, and weight loss over several weeks. Laboratory tests show glucose 620 mg/dL, sodium 130 mEq/L, p...

Question

A 42-year-old man presents with polyuria, polydipsia, and weight loss over several weeks. Laboratory tests show glucose 620 mg/dL, sodium 130 mEq/L, potassium 4.6 mEq/L, bicarbonate 22 mEq/L, and serum osmolality 320 mOsm/kg. There are no ketones in the urine. What is the most likely diagnosis?

Accepted Answer

Hyperosmolar hyperglycemic state

Answer

Diabetic ketoacidosis

Answer

Central diabetes insipidus

Answer

Primary polydipsia

Answer

Normal variant

us-abfm MCQ (SBA): Hyperosmolar hyperglycemic state

A 42-year-old man presents with polyuria, polydipsia, and weight loss over several weeks. Laboratory tests show glucose 620 mg/dL, sodium 130 mEq/L, potassium 4.6 mEq/L, bicarbonate 22 mEq/L, and serum osmolality 320 mOsm/kg. There are no ketones in the urine. What is the most likely diagnosis?