Question

A 62-year-old man with HFrEF (EF 30%) on ACE inhibitor and beta-blocker is being switched to sacubitril/valsartan. What is required at the time of switch?

Accepted Answer

Allow a 36-hour washout before starting sacubitril/valsartan

Answer

Start sacubitril/valsartan immediately after last ACE dose

Answer

Overlap ACE inhibitor and ARNI for 24 hours

Answer

Stop beta-blocker first

Answer

Start at maximum ARNI dose immediately

Practice question

A 62-year-old man with HFrEF (EF 30%) on ACE inhibitor and beta-blocker is being switched to sacubitril/valsartan. What is required at the time of switch?