A 71-year-old woman on apixaban 5 mg BID for AF requires elective colon cancer resection (high bleeding-risk procedure). CrCl is 80 mL/min. How should...

Question

A 71-year-old woman on apixaban 5 mg BID for AF requires elective colon cancer resection (high bleeding-risk procedure). CrCl is 80 mL/min. How should apixaban be managed?

Accepted Answer

Stop apixaban morning of surgery only

Answer

Continue apixaban; no interruption

Answer

Hold apixaban for 24 hours prior

Answer

Hold apixaban for 48 hours prior to surgery

Answer

Bridge with therapeutic LMWH during hold period

us-abim MCQ (SBA): Perioperative anticoagulation

A 71-year-old woman on apixaban 5 mg BID for AF requires elective colon cancer resection (high bleeding-risk procedure). CrCl is 80 mL/min. How should apixaban be managed?