Question

A 26-year-old woman with newly diagnosed ulcerative colitis is hospitalized with severe flare. Before starting biologic therapy, stool test is positive for C. difficile toxin. Best next step?

Accepted Answer

Treat C. difficile with fidaxomicin or vancomycin first

Answer

Start corticosteroids alone

Answer

Start anti-TNF immediately and ignore CDI

Answer

Start metronidazole only

Answer

Defer CDI therapy until after colonoscopy

Practice question

A 26-year-old woman with newly diagnosed ulcerative colitis is hospitalized with severe flare. Before starting biologic therapy, stool test is positive for C. difficile toxin. Best next step?