Question

A 33-year-old GBS-positive pregnant patient presents in labor with penicillin allergy (anaphylaxis). Culture shows clindamycin-resistant isolate. Best intrapartum prophylaxis?

Accepted Answer

Vancomycin 20 mg/kg IV q8h (adjust for renal function)

Answer

Penicillin G 5 million units IV load, then 2.5-3 million units q4h

Answer

Ampicillin 2 g IV load, then 1 g q4h

Answer

Clindamycin 900 mg IV q8h

Answer

No antibiotic prophylaxis needed if afebrile

Practice question

A 33-year-old GBS-positive pregnant patient presents in labor with penicillin allergy (anaphylaxis). Culture shows clindamycin-resistant isolate. Best intrapartum prophylaxis?