Question

A 64-year-old hospitalised patient develops nonsevere Clostridioides difficile infection (6 watery stools/day; WBC 12,000/µL; creatinine at baseline). What is the preferred initial therapy?

Accepted Answer

Fidaxomicin 200 mg PO twice daily for 10 days

Answer

Metronidazole 500 mg PO three times daily for 10 days

Answer

Vancomycin 125 mg PO four times daily for 10 days plus metronidazole IV

Answer

Vancomycin 250 mg PO four times daily for 14 days

Answer

Bezlotoxumab infusion as monotherapy

Practice question

A 64-year-old hospitalised patient develops nonsevere Clostridioides difficile infection (6 watery stools/day; WBC 12,000/µL; creatinine at baseline). What is the preferred initial therapy?