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Moderate"ADA recommends metformin plus lifestyle as initial therapy for most patients without organ-specific indications requiring other agents. Insulin is not first-line here (A). SGLT2 or GLP-1 RA are considered with compelling indications or intolerance (CDiabetes Mellitus"endocrinology"

A 58-year-old woman with new diagnosis of diabetes (A1c 7.2%) has no ASCVD, CKD or HF. BMI 29 kg/m². Preferred initial therapy?

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