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Moderate"B"nitrofurantoin 100 mg BID for 5 days is first-line. Amoxicillin is not first-line due to resistance (A). Fluoroquinolones are reserved for more serious infections (C). Ceftriaxone is for pyelonephritis/complicated cases (D). TMP-SMX is first-line for 3 days where local resistance is low; 14 days is excessive (E)."idsa guideline (2011

A 27-year-old presents with 3 days of dysuria and urinary frequency, afebrile, nonpregnant, no flank pain. UA is positive for leukocyte esterase and nitrite. Best empiric therapy?

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