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Moderate"Probiotics only"IDSA/SHEA prioritize fidaxomicin as preferred initial therapy for nonsevere CDI; oral vancomycin is acceptable alternative typically for 10 days. Metronidazole (A) is no longer preferred. Five-day vancomycin (C) is too short. IV vancomycin (D) does not treat colonic CDI. Probiotics alone (E) are not treatment."idsa guideline (2021): clostridioides difficile infection"

A 56-year-old hospitalized with suspected C. difficile infection has ≥3 unformed stools/day, WBC 13,000, creatinine 1.1. First episode nonsevere. Best initial therapy?

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