Question

A 42-year-old with severe CAP and septic shock is started on broad-spectrum therapy. When should initial combination MRSA/antipseudomonal coverage be de-escalated?

Accepted Answer

After 24-48 h if cultures and risk assessment do not support resistant pathogens

Answer

Never de-escalate

Answer

Only after 14 days

Answer

At discharge

Answer

After radiographic resolution

Practice question

A 42-year-old with severe CAP and septic shock is started on broad-spectrum therapy. When should initial combination MRSA/antipseudomonal coverage be de-escalated?