A 45-year-old with new HFrEF (EF 28%) is on lisinopril. You plan to start sacubitril/valsartan. What is required?...

Question

A 45-year-old with new HFrEF (EF 28%) is on lisinopril. You plan to start sacubitril/valsartan. What is required?

Accepted Answer

Hold ACE inhibitor for >=36 hours before starting ARNI

Answer

Start ARNI immediately with ACE inhibitor overlap

Answer

Stop beta-blocker first

Answer

Check BNP only; no washout needed

Answer

Start at highest dose regardless of BP

us-abim MCQ (SBA): Heart Failure-ARNI Transition