A 58-year-old man reports three gout flares in the past year. Serum urate is 9.2 mg/dL between flares, eGFR 70 mL/min/1.73 m2. What is the best diseas...

Question

A 58-year-old man reports three gout flares in the past year. Serum urate is 9.2 mg/dL between flares, eGFR 70 mL/min/1.73 m2. What is the best disease-modifying approach?

Accepted Answer

Initiate allopurinol 100 mg daily and titrate to serum urate

Answer

Start febuxostat 80 mg daily as first-line

Answer

Begin probenecid 500 mg twice daily

Answer

Treat flares only; avoid urate-lowering therapy unless tophi develop

Answer

Start pegloticase now

us-usmle-step-2 MCQ (SBA): Gout

A 58-year-old man reports three gout flares in the past year. Serum urate is 9.2 mg/dL between flares, eGFR 70 mL/min/1.73 m2. What is the best disease-modifying approach?