A 68-year-old hospitalized woman develops her first episode of nonsevere Clostridioides difficile infection (WBC 11,000/µL, creatinine 1.2 mg/dL). She...

Question

A 68-year-old hospitalized woman develops her first episode of nonsevere Clostridioides difficile infection (WBC 11,000/µL, creatinine 1.2 mg/dL). She is hemodynamically stable. Optimal initial therapy?

Accepted Answer

Oral fidaxomicin 200 mg twice daily for 10 days

Answer

Oral vancomycin 125 mg QID for 10 days (preferred over fidaxomicin)

Answer

Metronidazole 500 mg PO TID for 14 days

Answer

Probiotics as monotherapy

Answer

Fecal microbiota transplant now

us-usmle-step-2 MCQ (SBA): Clostridioides difficile Infection

A 68-year-old hospitalized woman develops her first episode of nonsevere Clostridioides difficile infection (WBC 11,000/µL, creatinine 1.2 mg/dL). She is hemodynamically stable. Optimal initial therapy?