A 51-year-old with obesity (BMI 34), refractory to lifestyle therapy, has T2DM and ASCVD. Which antiobesity medication class has strongest evidence fo...

Question

A 51-year-old with obesity (BMI 34), refractory to lifestyle therapy, has T2DM and ASCVD. Which antiobesity medication class has strongest evidence for ≥10% weight loss and CV benefit?

Accepted Answer

GLP-1 receptor agonist (e.g., semaglutide)

Answer

Phentermine/topiramate

Answer

Orlistat

Answer

Bupropion/naltrexone

Answer

None have CV benefit

us-abfm MCQ (SBA): Obesity Pharmacotherapy

A 51-year-old with obesity (BMI 34), refractory to lifestyle therapy, has T2DM and ASCVD. Which antiobesity medication class has strongest evidence for ≥10% weight loss and CV benefit?