Question

A 57-year-old hospitalized patient develops a first episode, non-severe Clostridioides difficile infection (WBC 10,500/µL; creatinine normal). Which initial antibiotic therapy is preferred?

Accepted Answer

Fidaxomicin 200 mg PO BID for 10 days

Answer

Metronidazole 500 mg PO TID for 10 days

Answer

Vancomycin 125 mg PO QID for 10 days

Answer

Vancomycin 500 mg PO QID plus IV metronidazole

Answer

Rifaximin 400 mg PO TID for 10 days

Practice question

A 57-year-old hospitalized patient develops a first episode, non-severe Clostridioides difficile infection (WBC 10,500/µL; creatinine normal). Which initial antibiotic therapy is preferred?