Question

A 67-year-old hospitalized patient has a first episode of nonsevere Clostridioides difficile infection (WBC 12,000/µL, creatinine normal). Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg PO twice daily for 10 days.

Answer

Metronidazole 500 mg PO three times daily for 10 days.

Answer

Vancomycin 125 mg PO four times daily for 10 days (preferred over fidaxomicin).

Answer

Vancomycin 125 mg PO four times daily plus IV metronidazole.

Answer

Fecal microbiota transplantation as first-line.

Practice question

A 67-year-old hospitalized patient has a first episode of nonsevere Clostridioides difficile infection (WBC 12,000/µL, creatinine normal). Best initial therapy?